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11/24/2015 Comments

Fixing the Microbial Tally in Our Guts

By Uma Chandrasekaran

Greek philosopher Thales once said “A sound mind in a sound body”, suggesting that mental and physical well-being are closely linked. The recent discoveries made by scientists on the gut microbial community in humans have made us believe, “A sound gut for a sound body”.
 
‘Gut microbes influence obesity’, ‘Gut bacteria and cancer incidence’, ‘Gut bacteria guide your mind’, ‘Diabetes start in your Gut’, ‘Gut bacteria signal Asthma Risk’ and the list goes on. In all, gut microbial community or intestinal microflora is emerging as a major pivot between health and disease.

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9/23/2015 Comments

Excavating The Human Immune ArchiveĀ 

Picture
LLPCs maintain a “historical record” of disease exposure in the Bone Marrow (Image credit: University of Michigan Health System)
By Uma Chandrasekaran

Ebola outbreak. SARS epidemic. Swine-flu pandemic. If these weren’t enough to claim our lives, re-emergence of measles, polio, whooping cough and, of course the ever-changing strains of flu always poses a threat.

In stark contrast, according to WHO, the global life expectancy at birth in 2013 has risen to 71 years from a mere 20-35 years at the turn of the century1,2. How do these two pieces of data fit together?

It turns out that we are not dead yet, because of the advancements in the field of medicine, specifically, the discovery of vaccines. Many of us would have received the kiss of death from small pox or rabies - if not for vaccines, well before we hit the five-year milestone. Despite coming out in the clear from the commonly afflicted childhood communicable diseases, human races’ ever-raging battles with the microbial and viral communities continue throughout our lifetime. Vaccines are the prime tried and tested arsenal for humans in this battle.


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8/19/2015 Comments

Drugs in Our Pipeline: Consequence of Advancement in Science

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Original image credit: https://s-media-cache-ak0.pinimg.com/236x/7b/e6/f4/7be6f4f4a7ee69ef9703d35dee917f71.jpg
By Uma Chandrasekaran

Long gone are the days of saying that an “apple a day keeps the doctor away”. Modern day science has transformed our lives. They have made us believe, “pill a day keeps the disease at bay”. Not just drugs, but our day-to-day existence is unimaginable without a myriad of personal care products (PPCPs) like antibacterials, antiperspirants and sunscreen.

Turns out, these pharmaceutical drugs and personal care products, in addition to adorning our household cabinets, also spill out into our waterways. Their journey does not end there. This uncanny mixture of assorted chemicals finds its way to our rivers only to turn them into a  “chemical soup.”  

According to a recent study [1], a total of 93 pharmaceuticals (concentration range:0.35-15,000 ng/L) ranging from caffeine to prescription drugs (antibiotics, anti-depressants and contraceptives) to disinfectants contaminate the surface waters of the USA. 

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